Consortium

Co-ordinators: The University of Manchester

Principal Investigator

Professor Sabine Flitsch

Professor Sabine Flitsch

Professor of Chemical Biology

Sabine’s interests lie in the use of a high-throughput glycan array mass spectrometry screening platform for study of glycoenzyme activities.

Professor Nicholas Turner

Professor Nicholas Turner

Professor of Chemical Biology

Nick brings considerable expertise in using synthetic biology to produce designer enzymes with tailored characteristics/specificities.

Project Management

Dr. Hannah Roberts

Dr. Hannah Roberts

Scientific Project Manager

Hannah is primarily involved in the overall management of the grant with particular focus on the commercialisation of results.

Postdoctoral Scientist

Dr. Peter Both

Dr. Peter Both

Research Associate

Peter is working on the discovery of glycozymes for biosynthesis and functional studies of medically-relevant glycans.

Academic Project Partner: John Innes Centre

Principal Investigator

Professor Rob Field

Professor Rob Field

Professor of Chemical Biology

Expertise in the development and application of tool-kits of glycoenzyme inhibitors, spectroscopic and mass spectrometric techniques in order to better understand and exploit carbohydrate-active enzymes.

Postdoctoral Scientist

Dr Giulia Pergolizzi

Dr Giulia Pergolizzi

Research Associate

Giulia is focusing on new enzymes to interpenetrate start-cellulose gels to produce stable enzymes for Kg scale.

Academic Project Partner: Institute of Food Research

Principal Investigator

Dr Nathalie Juge

Dr Nathalie Juge

Research Leader

Natalie has worked extensively on glycoenzymes involved in cell wall degradation and currently has a strong interest in glycosidases in the gut microbiome.

Postdoctoral Scientist

Dr Devon Kavanaugh

Dr Devon Kavanaugh

Research Associate

Devon is focusing on mucin-degrading enzymes in gut bacteria.

Academic Project Partner: The University of Newcastle

Principal Investigator

Dr David Bolam

Dr David Bolam

Senior Lecturer

David studies the molecular mechanisms utilised by our resident gut bacteria to recognise, acquire and degrade complex glycans.

Postdoctoral Scientist

Dr Lucy Crouch

Dr Lucy Crouch

Research Associate

Lucy is looking at PULs associated with N-glycan and/or O-glycan degradation

Industry Project Partner: Ludger Ltd.

Principal Investigator

Dr Daniel Spencer

Dr Daniel Spencer

Head of Development

Ludger are testing the efficacy of the glycoenzymes for use in diagnostic test kits and for commercialisation as well as designing and curating the glycoenzymes database.

Industry Project Partner: Biocatalysts Ltd.

Principal Investigator

Dr Andrew Ellis

Dr Andrew Ellis

Technical Director

Biocatalysts interest lie in enzymes for the production/functionalisation of food and beverages.

Subcontractor: Prozomix Ltd.

Principal Investigator

Dr Simon Charnock

Dr Simon Charnock

Managing Director

Prozomix supply the discovery and production of novel enzymes for validation by academic partners.